教學時程、閱讀資料、課堂講稿
細胞間質力學
因舊版課程無指定課堂作業與考試，因此統整所有作業、講義、考試內容合併列出。
細胞間質力學
因舊版課程無指定課堂作業與考試，因此統整所有作業、講義、考試內容合併列出。
|
課 |
課程單元 |
講師 |
重要日期 課堂講稿 |
閱讀資料 |
|
單位細胞的變化過程和細胞基質分子和組織結構的力學 I. Unit Cell Processes and Mechanics of Matrix Molecules and Tissues Structures |
||||
|
1 |
在組織和器官中機械力所扮演角色的臨床例子：有用範例 Clinical Examples of the Roles of Mechanical Forces in Tissues and Organs: The Working Paradigms
|
Spector教授 |
(英 PDF) |
Spector的筆記(英 PDF) |
|
2 |
組織結構和單位細胞的變化 Tissue Structures and Unit Cell Processes
|
Spector教授 |
(英 PDF 1)
(英 PDF 2)
(英 PDF 3) |
Spector的筆記(英 PDF) |
|
3 |
細胞基質與細胞的交互作用： 細胞間基質的分子，粘連蛋白質和整聯蛋白 Cell-Matrix Interactions: Extracellular Matrix Molecules, Adhesion Proteins and Integrins
|
Spector教授 |
(英 PDF 1)
(英 PDF 2) |
Spector Stossel, Thomas P.〈關於動物細胞的分佈不均〉"On the Crawling of Animal Cells." 《科學》新系列 Science, New Series, 260, no. 5111 (May五月 21, 1993): 1086-1094.
Hinz, Boris, Giuseppe Celetta, James J. Tomasek, Giulio Gabbiani, and Christine Chaponnier.〈α—平滑肌肌動蛋白表現上調纖維母細胞收縮活動〉"Alpha-Smooth Muscle Actin Expression Upregulates Fibroblast Contractile Activity." 《細胞分子生物學》Molecular Biology of the Cell 12 (September9月 2001): 2730-2741.
Vale, Ronald D., and Ronald A. Milligan. 〈物體活動的方式：對分子動力蛋白質的研究〉 "The Way Things Move: Looking Under the Hood of Molecular Motor Proteins." 《科學》Science 288 (April四月 7, 2000).
|
|
4 |
關於可滲透架構的機械表現模型 Models for the Mechanical Behavior of Porous Scaffolds
|
L. Gibson教授 |
交第一次家庭作業 (英 PDF) |
|
|
5 |
組織中結構與特性的關係 Structure-Properties Relationships for Tissues
|
Spector教授 |
|
|
|
6 |
一些特定組織的力學 Mechanics of Selected Tissues
|
S. Socrate教授 |
|
|
|
細胞力學：引起細胞內源機械力和外源機械力的作用 II. Mechanics of Cells: Effects of Exogenous Forces and Endogenous Force Generation |
||||
|
7 |
作用在細胞上的外源機械力的作用 Effects of Exogenous Mechanical Forces on Cells
|
Spector教授 |
交第二次作業
|
Spector的筆記(英 PDF) |
|
8 |
細胞對基底應變作用的反應 Response of Cells to Substrate Strain |
Spector教授 |
(英 PDF)
|
Banes, Albert J., Mari Tsuzaki, Juro Yamamoto, Thomas Fischer, Brian Brigman, Thomas Brown, and Larry Miller. 〈分子層級的機械性感受：對機械信號反應的偵測、解釋和多樣性〉Mechanoreception at the Cellular Level: The Detection,Interpretation, and Diversity of Responses to Mechanical Signals." 《細胞生物化學》Biochem Cell Biol 73 (1995): 349-365.
Davies, Peter F., and Satish C. Tripathi. 〈機械壓力結構和細胞—內皮的範例〉"Mechanical Stress Mechanisms and the Cell - An Endothelial Paradigm."《循環研究》Circulation Research 72, no. 2 (February, 1993): 239-245.
Wang, Ning, James P. Butler, and Donald E. Ingber. 〈遍佈細胞表面和穿過細胞支架的機械力傳導〉"Mechanotransduction Across the Cell Surface and Through the Cytoskeleton." 《科學》新系列Science, New Series, 260, no. 5111 (May 21, 1993): 1124-1127.
Alenghat, Francis J., and Donald E. Ingber. 〈機械力傳導：所有有關細胞支架、細胞基質的信號〉"Mechanotransduction: All Signals Point to Cytoskeleton, Matrix, and Integrins."《科學，科學訊息傳遞環境》Sciences, STKE (Feb 12, 2002).
Schaffer, Jonathan L., Michael Rizen, Gilbert J. L'Italien, Aziz Benbrahim, Joseph Megerman, Louis C. Gerstenfeld, and Martha L. Gray. 〈雙軸動力的均勻性和等相應變裝置應用於變異性細胞培養膜〉"Device for the Application of a Dynamic Biaxially Uniform and Isotropic Strain to a Flexible Cell Culture Membrane." 《整形學研究期刊》Journal of OrthoPaedic Research 12: 709-719.
McNeil, Paul L., and Richard A. Steinhardt. 〈失去、還原和對血漿細胞完整性的保持〉"Loss, Restoration, and Maintenance of Plasma Membrane Integrity." 《細胞生物期刊》 The Journal of Cell Biology 137, no. 1 (April 7, 1997): 1-4.
McNeil, Paul L., and Richard A. Steinhardt. 〈血漿細胞細胞膜的混亂：修復、預防、適應性〉"Plasma Membrane Disruption: Repair, Prevention, Adaptation." 《細胞發展生物學年度評論》 Annu Rev. Cell Dev. Biol. 19 (July 8, 2003): 697-731.
Miyake, Katsuya, and Paul L. McNeil. 〈細胞的機械損傷和修復〉 "Mechanical Injury and Repair of Cells." 《重症監護醫學》 Crit Care Med 31, no. 8 (Suppl. 2003).
|
|
9 |
細胞內皮對流動的反應 Endothelial Cell Response to Flow
|
C. F. Dewey教授 |
|
|
|
10 |
第一次小測驗
|
|
|
|
|
11 |
對細胞收縮的計量 Measuring Cell Contraction
細胞力監視器 Cell Force Monitor
|
Brendan Harley |
(英 PDF) |
|
|
12 |
Endogenous Mechanical Force Generation by Cells 由細胞產生的內源機械力
|
Spector教授 |
(英 PDF 1)
(英 PDF 2)
|
|
|
13 |
體外的（試管內的）和體內的細胞收縮模型 Models for Cell Contraction In Vitro and In Vivo
|
Spector教授 |
(英 PDF 1)
(英 PDF 2) |
|
|
14 |
細胞基質與細胞的機械耦合 Mechanical Coupling of Cells with Matrix
|
Yannas教授 |
(英 PDF 1)
(英 PDF 2) |
Yannas，第8章 |
|
15 |
創傷終止時細胞與細胞基質的交互作用 Cell-matrix Interactions During Wound Closure
|
Yannas教授 |
Yannas，第9章 |
|
|
16 |
在誘使器官再生過程中細胞收縮受阻 Blockade of Contraction During Induced Organ Regeneration
|
Yannas教授 |
Yannas，第9章 |
|
|
17 |
復習Review |
Spector教授 |
|
Oliver, Tim, Juliet Lee, and Ken Jacobson. 〈移動細胞運用的力〉 "Forces Exerted by Locomoting Cells." 《細胞生物學》 Cell Biology 5 (1994): 139-147. Rutherford, Dr. Jack. "Structure and Function of Skeletal Muscle." 〈骨骼肌的結構和功能〉 (PPT) Wu, Richard C. "Physiology of smooth muscle. 〈平滑肌生理學〉"(PPT)
|
|
18 |
第二次考試
|
|
|
|
|
III. 組織力學Tissue Mechanics |
|
|||
|
19 |
復習線性彈性力學原理 Review of Principles of Linear Elastic Mechanics
|
Yannas教授 |
Yannas，第10章 |
|
|
20 |
非線性的彈力：腱和皮膚 Nonlinear Elasticity: Tendon and Skin
|
Yannas教授 |
(英 PDF)
|
Yannas，第11章 |
|
21 |
線性的粘膠液彈力的表現 Linear Viscoelastic Behavior
|
Yannas教授 |
Yannas，第9章 |
|
|
22 |
對機械力負載的關節軟骨的反應 Response of Articular Cartilage to Mechanical Loading
|
A. Grodzinsky教授 |
(英 PDF) |
|
|
23 |
韌帶、半月軟骨、椎間盤的機械表現 Mechanical Behavior of Ligament, Meniscus and Intervertebral Disc
|
Spector教授 |
(英 PDF 1)
(英 PDF 2)
|
|
|
24 |
骨骼的機械表現 Mechanical Behavior of Bone |
Spector教授 |
Homework 3 due 交第三次家庭作業 (英 PDF) |
|
|
25 |
骨骼對機械負載的反應 Response of Bone to Mechanical Loading 復習
|
Spector教授 |
(英 PDF)
|
|
|
26 |
第三次測驗 |
|
|
|