作業
老化之神經學、神經生理學、神經生物學
因舊版課程無指定課堂作業與考試,因此統整所有作業、講義、考試內容合併列出。
老化之神經學、神經生理學、神經生物學
因舊版課程無指定課堂作業與考試,因此統整所有作業、講義、考試內容合併列出。
作業設計的目的在於讓學生能專注於本領域的原始文獻。每個學生應該提出下列文獻的心得發現。 The assignments are designed to immerse the student in primary literature of the field. From this literature each student will present their findings.
學生報告 Student Presentations
學生應該基於閱讀材料提交自己的報告主題。課堂報告的內容應基於課程,原始文獻,和課堂討論。主題可包括人腦老化中的記憶和其他認知能力的喪失;神經退化疾病如帕金森氏症和阿茲海莫症。 Students are expected to present topics in class, based on the readings found in the list below. Presentations are based on lectures, readings taken from the primary literature, and class discussions. Some of the topics include loss of memory and other cognitive abilities in normal aging; and neurodegenerative conditions, such as Parkinson's and Alzheimer's diseases.
主題 Topics
學生應繳交一份下列文章的摘要。 Students present a short synopsis of the following articles.
Bard, F., C. Cannon, R. Barbour, R. L. Burke, D. Games, H. Grajeda, T. Guido, K. Hu, J. Huang, 等 〈利用週邊注入類澱粉胜肽抗體進入阿茲海莫症老鼠中樞神經系統以降低病理變化〉,《自然醫學》 6(8) (2000): 916-9. Bard, F., C. Cannon, R. Barbour, R. L. Burke, D. Games, H. Grajeda, T. Guido, K. Hu, J. Huang, et al. "Peripherally administered antibodies against amyloid ®-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease." Nat Med 6(8) (2000): 916-9.
Blanchard, B. J., A. E. Hiniker, C. C. Lu, Y. Margolin, A. S. Yu, 與 V. M. Ingram. 〈去除類澱粉胜肽之神經毒性〉,《阿茲海莫症雜誌》. 2(2) (2000): 137-149. Blanchard, B. J., A. E. Hiniker, C. C. Lu, Y. Margolin, A. S. Yu, and V. M. Ingram. "Elimination of Amyloid ® Neurotoxicity." J Alzheimers Dis. 2(2) (2000): 137-149.
Blanchard, B. J., G. Konopka, M. Russell, 與 V. M. Ingram. 〈與阿茲海莫症有關之類澱粉胜肽的機轉與神經毒性預防〉, 《腦部研究》. 776(1-2) (1997): 40-50. Blanchard, B. J., G. Konopka, M. Russell, and V. M. Ingram. "Mechanism and prevention of neurotoxicity caused by ®-amyloid peptides: relation to Alzheimer's disease." Brain Res. 776(1-2) (1997): 40-50.
Citron, M., T. Oltersdorf, C. Haass, L. McConlogue, A. Y. Hung, P. Seubert, C. Vigo-Pelfrey, I. Lieberburg, 與 D. J. Selkoe. 〈類澱粉胜肽前驅蛋白質基因突變對阿茲海莫症病人類澱粉胜肽生成增加之影響〉,《自然》 360(6405) (1992): 672-4. Citron, M., T. Oltersdorf, C. Haass, L. McConlogue, A. Y. Hung, P. Seubert, C. Vigo-Pelfrey, I. Lieberburg, and D. J. Selkoe. "Mutation of the ®-amyloid precursor protein in familial Alzheimer's disease increases ®-protein production." Nature 360(6405) (1992): 672-4.
Hartley, D. M., D. M. Walsh, C. P. Ye, T. Diehl, S. Vasquez, P. M. Vassilev, D. B. Teplow, 與 D. J. Selkoe. 〈類澱粉胜肽的中間絲引起大腦皮質細胞急性電器生理變化進行性神經毒性〉,《神經科學雜誌》 19(20) (1999): 8876-84. Hartley, D. M., D. M. Walsh, C. P. Ye, T. Diehl, S. Vasquez, P. M. Vassilev, D. B. Teplow, and D. J. Selkoe. "Protofibrillar intermediates of amyloid ® -protein induce acute electrophysiological changes and progressive neurotoxicity in cortical neurons." J Neurosci 19(20) (1999): 8876-84.
Morgan, D., 等 〈在阿茲海莫症動物模型上試驗胜肽疫苗以避免記憶喪失〉,《自然》 408(6815) (2000): 982-5. Morgan, D., et al. "A ® peptide vaccination prevents memory loss in an animal model of Alzheimer's disease." Nature 408(6815) (2000): 982-5.
Schenk, D., 等 〈利用免疫活化降低類澱粉胜肽之功能觀察在PDAPP老鼠之類阿茲海莫症病理變化〉,《自然》 400(6740) (1999): 173-7. Schenk, D., et al. "Immunization with amyloid-® attenuates Alzheimerdisease- like pathology in the PDAPP mouse." Nature 400(6740) (1999): 173-7.
Selkoe.〈第三部:分泌酶的抑制〉 556-564. Selkoe. "Part 3: Inhibition of ©-Secretase." 556-564.
Selkoe.〈第四部:免疫方向對治療的想法〉 564-571. Selkoe. "Part 4: Immunological Approach to Therapy." 564-571.
Selkoe.〈第五部:其他方向對治療的想法〉 571-576. Selkoe. "Part 5: Other Approaches to Therapy." 571-576.
Sherrington, R., E. I. Rogaev, Y. Liang, E. A. Rogaeva, G. Levesque, M. Ikeda, H. Chi, C. Lin, G. Li, K. Holman, 等 〈複製一個突然變異基因於早發性家族性阿茲海莫症之研究〉,《自然》 375(6534) (1995 ): 754-60. Sherrington, R., E. I. Rogaev, Y. Liang, E. A. Rogaeva, G. Levesque, M. Ikeda, H. Chi, C. Lin, G. Li, K. Holman, et al. "Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease." Nature 375(6534) (1995 ): 754-60.
Walsh, D. M., I. Klyubin, J. V. Fadeeva, W. K. Cullen, R. Anwyl, M. S. Wolfe, M. J. Rowan, 與 D. J. Selkoe. 〈自然分泌之類澱粉胜肽的寡分子抑制海馬迴細胞長期的活力之動物體內實驗〉,《自然》 416(6880) (2002): 535-9. Walsh, D. M., I. Klyubin, J. V. Fadeeva, W. K. Cullen, R. Anwyl, M. S. Wolfe, M. J. Rowan, and D. J. Selkoe. "Naturally secreted oligomers of amyloid ® protein potently inhibit hippocampal long-term potentiation in vivo." Nature 416(6880) (2002): 535-9.
Yan, R., P. Han, H. Miao, P. Greengard, 與 H. Xu. 〈阿茲海莫症分泌酶之穿膜主體決定晚期高基氏體位置以及類澱粉胜肽前驅蛋白質基質〉,《生化學雜誌》. 276(39) (2001) : 36788-96. Yan, R., P. Han, H. Miao, P. Greengard, and H. Xu. "The transmembrane domain of the Alzheimer's ®-secretase (BACE1) determines its late Golgi localization and access to ®-amyloid precursor protein (APP) substrate." J Biol Chem. 276(39) (2001) : 36788-96. |