相關閱讀資料

學習與發育的神經可塑性

因舊版課程無指定課堂作業與考試，因此統整所有作業、講義、考試內容合併列出。

本頁列出的閱讀資料提供了課程的基本需求。直接點閱論文的連結，可以閱讀該論文的摘要。閱讀資料依題目順序列出。

The readings listed below provide the foundation of this course. Click on the links to view abstracts for the journal articles, where available. Readings are arranged by topic.

教科書

Bear, M., B. Connors, and M. Paradiso. 《神經科學，探索腦部》（Neuroscience, Exploring the Brain.） Williams and Wilkens, 2000.
Bear, M., B. Connors, and M. Paradiso. Neuroscience, Exploring the Brain. Williams and Wilkens, 2000.

突觸的可塑性 I
Synaptic Plasticity I

Albright, T. D., T. M. Jessell, E. R. Kandel, and M. I. Posner.「神經科學：一世紀以來的發展與尚未解開的謎團」Neuron 神經元. 25, 2000, Suppl: S1-55.
Albright, T. D., T. M. Jessell, E. R. Kandel, and M. I. Posner. 「Neural science: a century of progress and the mysteries that remain.」 Neuron. 25, 2000, Suppl: S1-55.

Bear, M. F. 「大腦皮質中記憶儲存的突觸間交互作用基礎」 In Proc. Natl. Acad. Sci美國科學院院報. 93, USA, 1996, 13453-13459.
Bear, M. F. 「A synaptic basis for memory storage in the cerebral cortex.」 In Proc. Natl. Acad. Sci. 93, USA, 1996, 13453-13459.

Bi, G. Q., and M. M. Poo. 「海馬迴神經培養細胞中的突觸修飾作用：與棘波時機、神經元間的連結強度、和突觸後的細胞種類的相關性.」 J Neurosci 神經科學期刊. 18, 24, 1998, 10464-72.
Bi, G. Q., and M. M. Poo. 「Synaptic modifications in cultured hippocampal neurons: dependence on spike timing, synaptic strength, and postsynaptic cell type.」J Neurosci.18, 24, 1998, 10464-72.

Bliss, T. V., and G. L. Collingridge.「記憶的突觸模型：海馬迴的長期增益現象」Nature自然. 361, 6407, 1993, 31-9.
Bliss, T. V., and G. L. Collingridge. 「A synaptic model of memory: long-term potentiation in the hippocampus.」Nature. 361, 6407, 1993, 31-9.

Lichtman, J. W., and H. Colman.「突觸消減現象與持久記憶」Neuron神經元. 25, 2, 2000, 269-78.
Lichtman, J. W., and H. Colman. 「Synapse elimination and indelible Memory.」 Neuron.25, 2, 2000, 269-78.

Malenka, R. C., and R. A. Nicoll.「長時增益現象：十年的進展？」Science科學. 285, 1999, 1870-4.
Malenka, R. C., and R. A. Nicoll. 「Long-term potentiation--a decade of progress?」 Science. 285, 1999, 1870-4.

Markram, H., J. Lubke, M. Frotscher, and B. Sakmann.「藉由突觸後動作電位 (AP) 與興奮性突觸後電位 (EPSP) 的一致性來進行突觸效力的調控」Science科學. 275, 5297, 1997, 213-5.
Markram, H., J. Lubke, M. Frotscher, and B. Sakmann. 「Regulation of synaptic efficacy by coincidence of postsynaptic APs and EPSPs.」 Science. 275, 5297, 1997, 213-5.

Sanes, J. R., and J. W. Lichtman.「分子能夠解釋長期增益現象嗎？」 In Nat Neurosci自然．神經科學. 2, 1999, 597-604.
Sanes, J. R., and J. W. Lichtman. 「Can molecules explain long-term potentiation?」 In Nat Neurosci. 2, 1999, 597-604.

Zhang, L. I., H. W. Tao, et al. 「視覺輸入誘發視覺突觸的長期增益現象」 Nat Neurosci自然神經科學. 3, 7, 2000, 708-15.
Zhang, L. I., H. W. Tao, et al. 「Visual input induces long-term potentiation of developing retinotectal synapses.」 Nat Neurosci. 3, 7, 2000, 708-15.

Zucker, R. S. 「鈣離子與活性依賴型突觸可塑性」Curr. Opin. Neurobiol神經生物學現今觀點. 9, 1999, 305-313.
Zucker, R. S. 「Calcium- and activity-dependent synaptic plasticity.」 Curr. Opin. Neurobiol. 9, 1999, 305-313.

突觸的可塑性 II
Synaptic Plasticity II

Liao, D., N. A. Hessler, et al. 「海馬迴切片的CA1區域中，由配對誘發的長期增益作用時之突觸後靜止突觸的活化作用」 Nature自然. 375, 6530, 1995, 400-4.
Liao, D., N. A. Hessler, et al. 「Activation of postsynaptically silent synapses during pairing-induced LTP in CA1 region of hippocampal slice.」 Nature. 375, 6530, 1995, 400-4.

Martin, K. C., M. Barad, and E. R. Kandel. 「鄰近蛋白質合成和其在突觸可塑性中扮演的角色」 Curr Opin Neurobiol神經生物學現今觀點. 10, 2000, 587-92.
Martin, K. C., M. Barad, and E. R. Kandel. 「Local protein synthesis and its role in synapse-specific plasticity.」 Curr Opin Neurobiol. 10, 2000, 587-92.

Renger, J. J., C. Egles, et al. 「藉由影響AMPA受體活化作用改變神經傳遞物質分泌量造成的發育轉變增強突觸效力」 Neuron神經元. 29, 2, 2001, 469- 84.
Renger, J. J., C. Egles, et al. 「A developmental switch in neurotransmitter flux enhances synaptic efficacy by affecting AMPA receptor activation.」 Neuron. 29, 2, 2001, 469- 84.

Shi, S., Y. Hayashi, J. A. Esteban, and R. Malinow. 「海馬迴角錐神經元中調控AMPA受體至突觸的傳輸過程的受體次單元專一性」 Cell細胞. 105, 2001, 331-43.
Shi, S., Y. Hayashi, J. A. Esteban, and R. Malinow. 「Subunit-specific rules governing AMPA receptor trafficking to synapses in hippocampal pyramidal neurons.」 Cell. 105, 2001, 331-43.

Shi, S. H., Y. Hayashi, R. S. Petralia, S. H. Zaman, R. J. Wenthold, K. Svoboda, and R. Malinow. 「在突觸的NMDA受體活化後的AMPA受體之迅速脊柱傳送與重新分配」 Science科學. 284, 1999, 1811-6.
Shi, S. H., Y. Hayashi, R. S. Petralia, S. H. Zaman, R. J. Wenthold, K. Svoboda, and R. Malinow. 「Rapid spine delivery and redistribution of AMPA receptors after synaptic NMDA receptor activation.」 Science. 284, 1999, 1811-6.

Stevens, C. F. 「「神經傳遞物質的量子化釋放與長期增益作用」 Cell細胞. 72, 1993, Suppl: 55-63.
Stevens, C. F. 「Quantal release of neurotransmitter and long-term potentiation.」 Cell. 72, 1993, Suppl: 55-63.

海蝸牛的學習和記憶
Learning and Memory in Aplysia

Carew, T. J., R. D. Hawkins, and E. R. Kandel. 「海蝸牛防禦性收縮反射之各類古典制約作用間的差異性」 Science科學. 219, 4583, 28 Jan. 1983, 397-400.
Carew, T. J., R. D. Hawkins, and E. R. Kandel. 「Differential classical conditioning of a defensive withdrawal reflex in Aplysia californica.」Science. 219, 4583, 28 Jan. 1983, 397-400.

Dash, P. K., B. Hochner, and E. R. Kandel. 「注射cAMP反應型因子至海蝸牛感覺神經元的細胞核中會阻礙長期促進作用」Nature自然. 345, 6277, 21 Jun. 1990, 718-21.
Dash, P. K., B. Hochner, and E. R. Kandel. 「Injection of the cAMP-responsive element into the nucleus of Aplysia sensory neurons blocks long-term facilitation.」Nature. 345, 6277, 21 Jun. 1990, 718-21.

Hawkins, R. D., T. W. Abrams, T. J. Carew, and E. R. Kandel. 「海蝸牛古典制約作用的細胞機制：突觸前促進作用的活性依賴型放大作用」 Science科學. 219, 4583, 28 Ja. 1983, 400-5 .
Hawkins, R. D., T. W. Abrams, T. J. Carew, and E. R. Kandel. 「A cellular mechanism of classical conditioning in Aplysia: activity-dependent amplification of presynaptic facilitation.」 Science. 219, 4583, 28 Jan. 1983, 400-5 .

Martin, K. C., A. Casadio, E. Y. Zhu H, J. C. Rose, M. Chen, C. H. Bailey, and E. R. Kandel. 「海蝸牛感覺突觸至運動突觸的突觸專一性與長期促進作用：涉及記憶貯存時原位蛋白質合成過程中的一項功能」 Cell細胞. 91, 7, 26 Dec. 1997, 927-38.
Martin, K. C., A. Casadio, E. Y. Zhu H, J. C. Rose, M. Chen, C. H. Bailey, and E. R. Kandel. 「Synapse-specific, long-term facilitation of aplysia sensory to motor synapses: a function for local protein synthesis in memory storage.」 Cell. 91, 7, 26 Dec. 1997, 927-38.

果蠅的學習和記憶
Learning and Memory in Drosophila

Grotewiel, M. S., C. D. O. Beck, K. H. Wu, X-R. Zhu, and R. L. Davis. 「果蠅由整合素蛋白導引的短期記憶」 Nature自然. 391, 6666, 29 Jan. 1998, 455-60.
Grotewiel, M. S., C. D. O. Beck, K. H. Wu, X-R. Zhu, and R. L. Davis. 「Integrinmediated short-term memory in Drosophila.」 Nature. 391, 6666, 29 Jan. 1998, 455-60.

Liu, L., R. Wolf, R. Ernst, and M. Heisenberg. 「相關研究彙整：果蠅視覺學習的外界訊息歸納過程中需要蕈狀體的參與」 Nature自然. 400, 6746, 1999, 753-56.
Liu, L., R. Wolf, R. Ernst, and M. Heisenberg. 「Context generalization in Drosophila visual learning requires the mushroom bodies.」 Nature. 400, 6746, 1999, 753-56.

Quinn, W. G., and T. Tully. 「正常果蠅與突變果蠅的古典制約作用和記憶能力的差異性」 J Comp Physiol [A]比較生理學期刊 [A]. 1985 Sep;157(2):263-77.
Quinn, W. G., and T. Tully. 「Classical conditioning and retention in normal and mutant Drosophila melanogaster.」 J Comp Physiol [A]. 1985 Sep;157(2):263-77.

Waddell, S., J. D. Armstrong, T. Kitamoto, K. Kaiser, and W. G. Quinn. 「健忘症基因產物表現於果蠅腦內兩條對於記憶形成不可或缺的神經元中」 Cell細胞. 103, Nov. 2000, 805-813.
Waddell, S., J. D. Armstrong, T. Kitamoto, K. Kaiser, and W. G. Quinn. 「The amnesiac gene product is expressed in two neurons in the drosophila brain that are critical for Memory.」 Cell. 103, Nov. 2000, 805-813.

海馬迴 I
Hippocampus I

Frank, L. M., E. N. Brown, and M. Wilson.「海馬迴和內嗅皮質如何參與生物判斷行進路線的過程」 Neuron. 神經元27, 1, Jul. 2000, 169-78.
Frank, L. M., E. N. Brown, and M. Wilson. 「Trajectory encoding in the hippocampus and entorhinal cortex.」 Neuron. 27, 1, Jul. 2000, 169-78.

Mehta, M. R., M. C. Quirk, and M. A. Wilson.「與經驗形成相關的海馬迴接受區之不對稱形狀」 Neuron. 神經元 25, 3, Mar. 2000, 707-15.
Mehta, M. R., M. C. Quirk, and M. A. Wilson. 「Experience-dependent asymmetric shape of hippocampal receptive fields.」 Neuron. 25, 3, Mar. 2000, 707-15.

海馬迴 II
Hippocampus II

Louie, K., and M. A. Wilson. 「整個海馬迴於睡眠中的清醒快速動眼期進行暫時性的結構重複變化過程」 Neuron神經元. 29 1, Jan. 2001, 145-156.
Louie, K., and M. A. Wilson. 「Temporally Structured Replay of Awake Hippocampal Ensemble Activity during Rapid Eye Movement Sleep.」 Neuron. 29 1, Jan. 2001, 145-156.

Wilson, M. A., and B. L. McNaughton. 「睡眠時的海馬迴整體記憶之再度活化」 Science科學.265, 5172, 29 Jul. 1994, 676-9.
Wilson, M. A., and B. L. McNaughton. 「Reactivation of hippocampal ensemble memories during sleep.」 Science. 265, 5172, 29 Jul. 1994, 676-9.

齧齒動物的學習和記憶 I
Learning and Memory in Rodents I

Gilbert, P. E., and R. P. Kesner. 「齧齒動物海馬迴在牽涉外來刺激與空間定位之間的關係中建立的配對式關聯學習中所扮演的角色」 Behav Neurosci行為神經科學. 116, 1, Feb. 2002, 63-71.
Gilbert, P. E., and R. P. Kesner. 「Role of the rodent hippocampus in paired-associate learning involving associations between a stimulus and a spatial location.」 Behav Neurosci. 116, 1, Feb. 2002, 63-71.

Lee, I., and R. P. Kesner. 「海馬迴各個次區域中NMDA受體對於空間活動記憶的不同貢獻」 Nat Neurosci自然神經科學. 5, 2, Feb. 2002, 162-8.
Lee, I., and R. P. Kesner. 「Differential contribution of NMDA receptors in hippocampal subregions to spatial working memory.」 Nat Neurosci. 5, 2, Feb. 2002, 162-8.

McGaugh, J. L. 「世紀回顧——記憶固化作用研究進程」 Science科學. 287, 5451, 14 Jan. 2000, 248-51.
McGaugh, J. L. 「Memory -- a Century of Consolidation.」 Science. 287, 5451, 14 Jan. 2000, 248-51.

齧齒動物的學習和記憶 II
Learning and Memory in Rodents II

Day, M., and R. G. Morris. 「記憶鞏固與NMDA受體：遺傳學與藥理學研究方式的差異」 Science科學. 293, 5531, 3 Aug. 2001, 755.
Day, M., and R. G. Morris. 「Memory consolidation and NMDA receptors: discrepancy between genetic and pharmacological approaches.」 Science. 293, 5531, 3 Aug. 2001, 755.

Nader, K., G. E. Schafe, and J. E. LeDoux. 「記憶鞏固理論的不穩定性質」 Nat Rev Neurosci自然神經科學回顧. 1, 3, Dec. 2000, 216-9.
Nader, K., G. E. Schafe, and J. E. LeDoux. 「The labile nature of consolidation theory.」 Nat Rev Neurosci. 1, 3, Dec. 2000, 216-9.

Nader, K., G. E. Schafe, and J. E. LeDoux. 「驚懼記憶的形成涉及杏仁核中蛋白質合成過程，以便在恢復後能重新鞏固」 Nature自然. 406, 6797, 2000, 722-6.
Nader, K., G. E. Schafe, and J. E. LeDoux. 「Fear memories require protein synthesis in the amygdala for reconsolidation after retrieval.」 Nature. 406, 6797, 2000, 722-6.

Shimizu, E., Y. P. Tang, C. Rampon, and J. Z. Tsien. 「NMDA受體依賴型的突觸強化作用為記憶鞏固不可或缺的過程」 Science科學. 290, 5494, 2000, 1170-4.
Shimizu, E., Y. P. Tang, C. Rampon, and J. Z. Tsien. 「NMDA receptor-dependent synaptic reinforcement as a crucial process for memory consolidation.」 Science. 290, 5494, 2000, 1170-4.

計算模式建立
Computational Modeling

Foster, D. J., R. G. Morris, and P. Dayan. 「海馬迴依賴型的導航模型，此模型由時間差學習理論所建立」 Hippocampus海馬迴. 10, 1, 2000, 1-16.
Foster, D. J., R. G. Morris, and P. Dayan. 「A model of hippocampally dependent navigation, using the temporal difference learning rule.」 Hippocampus. 10, 1, 2000, 1-16.

O'Reilly, R. C., and J. W. Rudy. 「新皮質（思考性腦）與海馬迴的學習計算原理」 Hippocampus海馬迴. 10, 4, 2000, 389-97.
O'Reilly, R. C., and J. W. Rudy. 「Computational principles of learning in the neocortex and hippocampus.」 Hippocampus. 10, 4, 2000, 389-97.

靈長類的的學習和記憶 I
Learning and Memory in Primates I

Tomita, H., M. Ohbayashi, K. Nakahara, I. Hasegawa, and Y. Miyashita. 「前額葉皮質的綜合訊息在記憶提取過程中的調控」 Nature自然. 401, 6754, 14 Oct. 1999, 699-703.
Tomita, H., M. Ohbayashi, K. Nakahara, I. Hasegawa, and Y. Miyashita. 「Top-down signal from prefrontal cortex in executive control of memory retrieval.」 Nature. 401, 6754, 14 Oct. 1999, 699-703.

Wallis, J. D., K. C. Anderson, and E. K. Miller. 「前額葉皮質的單一神經元為抽象規則提供了解釋」 Nature. 自然 411, 6840, 21 Jun. 2001, 953-6.
Wallis, J. D., K. C. Anderson, and E. K. Miller. 「Single neurons in prefrontal cortex encode abstract rules.」 Nature. 411, 6840, 21 Jun. 2001, 953-6.

靈長類的的學習和記憶 II
Learning and Memory in Primates II

Bichot, N. P., J. D. Schall, and K. G. Thompson. 「成年恆河猴前額眼區藉由經驗誘導的形象特徵選擇性」 Nature自然. 381, 6584, 20 Jun. 1996, 697-9 .
Bichot, N. P., J. D. Schall, and K. G. Thompson. 「Visual feature selectivity in frontal eye fields induced by experience in mature macaques.」 Nature. 381, 6584, 20 Jun. 1996, 697-9 .

Freedman, D. J., M. Riesenhuber, T. Poggio, and E. K. Miller.「靈長類前額葉皮質中的視覺刺激之分類作用」 Science科學. 291, 5502, 12 Jan. 2001, 312-6.
Freedman, D. J., M. Riesenhuber, T. Poggio, and E. K. Miller. 「Categorical representation of visual stimuli in the primate prefrontal cortex." Science. 291, 5502, 12 Jan. 2001, 312-6.

本體感知系統在發展過程上的可塑性
Developmental Plasticity in the Somatosensory System

Allard, T., S. A. Clark, W. M. Jenkins, and M. M. Merzenich. 「在手術併指後的成年貓頭鷹猴之體感3b區域感知的重新組織」 J Neurophysiol神經生理學期刊. 66, 3, Sep. 1991, 1048-58.
Allard, T., S. A. Clark, W. M. Jenkins, and M. M. Merzenich. 「Reorganization of somatosensory area 3b representations in adult owl monkeys after digital syndactyly.」 J Neurophysiol. 66, 3, Sep. 1991, 1048-58.

Steinmetz, P. N., A. Roy, P. J. Fitzgerald, S. S. Hsiao, K. O. Johnson, and E. Niebur. 「在靈長類體感皮質中注意力會調整同期化神經元的激化」 Nature自然. 404, 6774, 9 Mar. 2000, 187-90.
Steinmetz, P. N., A. Roy, P. J. Fitzgerald, S. S. Hsiao, K. O. Johnson, and E. Niebur. 「Attention modulates synchronized neuronal firing in primate somatosensory cortex.」 Nature. 404, 6774, 9 Mar. 2000, 187-90.

視覺系統在發展過程上的可塑性
Developing Plasticity in the Visual System

Frank, M. G., N. P. Issa, and M. P. Stryker.「睡眠可強化其腦部視覺皮質在發育過程中的可塑性」 Neuron神經元. 30, 1, Apr. 2001, 275-87.
Frank, M. G., N. P. Issa, and M. P. Stryker. 「Sleep enhances plasticity in the developing visual cortex.」 Neuron. 30, 1, Apr. 2001, 275-87.

Huh, G. S., L. M. Boulanger, H. Du, P. A. Riquelme, T. M. Brotz, and C. J. Shatz. 「中樞神經系統發育與可塑性的第I型MHC的功能性需求」 Science科學. 290, 5499, 15 Dec. 2000, 2155-9.
Huh, G. S., L. M. Boulanger, H. Du, P. A. Riquelme, T. M. Brotz, and C. J. Shatz. 「Functional requirement for class I MHC in CNS development and plasticity.」 Science. 290, 5499, 15 Dec. 2000, 2155-9.