本課程介紹可於分子層級來瞭解細胞的基本電腦計算原理。包含了序列排比演算法、動態規劃、雜湊表、字尾樹、以及Gibbs取樣等主題。此外,本課程亦著重於計算方法如:基因與其物理位置之對映;基因體定序、重組及註解;RNA表現與二級結構;蛋白質結構與折疊;以及分子間的交互作用與動力學。
This course introduces the basic computational methods used to understand the cell on a molecular level. It covers subjects such as the sequence alignment algorithms: dynamic programming, hashing, suffix trees, and Gibbs sampling. Furthermore, it focuses on computational approaches to: genetic and physical mapping; genome sequencing, assembly, and annotation; RNA expression and secondary structure; protein structure and folding; and molecular interactions and dynamics.