10.492-2 2004秋季課程：整合化學工程專題I：生物觸媒導論(Integrated Chemical Engineering Topics I: Introduction to Biocatalysis, Fall 2004)
|
枯草桿菌脂?的結晶構造：最小的a/b水解酵素。PDB ID: 1I6W。 van Pouderoyen, G., T. Eggert, K. E. Jaeger, B. W. Dijkstra：枯草桿菌脂?的結晶構造：最小的alpha/beta摺疊水解酵素。《分子生物學期刊》 309, issue 1 (May 25, 2001): 215-26.（圖片提供：結構生物資訊研究共同實驗室，H.M.Berman, J.Westbrook, Z.Feng, G.Gilliland, T.N.Bhat, H.Weissig, I.N.Shindyalov, P.E.Bourne 蛋白質資料庫，《核酸研究》, 28 pp. 235-242 (2000).）
The Crystal Structure Of Bacillus Subtilis Lipase: A Minimal a/b Hydrolase Enzyme. PDB ID: 1I6W. van Pouderoyen, G., T. Eggert, K. E. Jaeger, B. W. Dijkstra: The crystal structure of Bacillus subtilis lipase: a minimal alpha/beta hydrolase fold enzyme. J. Mol. Biol. 309, issue 1 (May 25, 2001): 215-26. (Image courtesy of the Research Collaboratory for Structural Bioinformatics. Berman, H. M., J. Westbrook, Z. Feng, G. Gilliland, T. N. Bhat, H. Weissig, I. N. Shindyalov, and P. E. Bourne. "The Protein Data Bank." Nucleic Acids Research 28 (2000): 235-242.)
The Crystal Structure Of Bacillus Subtilis Lipase: A Minimal a/b Hydrolase Enzyme. PDB ID: 1I6W. van Pouderoyen, G., T. Eggert, K. E. Jaeger, B. W. Dijkstra: The crystal structure of Bacillus subtilis lipase: a minimal alpha/beta hydrolase fold enzyme. J. Mol. Biol. 309, issue 1 (May 25, 2001): 215-26. (Image courtesy of the Research Collaboratory for Structural Bioinformatics. Berman, H. M., J. Westbrook, Z. Feng, G. Gilliland, T. N. Bhat, H. Weissig, I. N. Shindyalov, and P. E. Bourne. "The Protein Data Bank." Nucleic Acids Research 28 (2000): 235-242.)
課程重點
課程描述
本課程將以程序設計觀點提供生物觸媒領域的簡介。基本的主題包括:為何及何時可能選擇使用生物系統來進行化學轉化、考量使用分離酵素或完整細胞，以及與設計和開發生物轉化程序相關的議題。課程中並將討論生物和工程的問題，以及如何才可能同時達成生物和工程的解決方案。
This course provides a brief introduction to the field of biocatalysis in the context of process design. Fundamental topics include why and when one may choose to use biological systems for chemical conversion, considerations for using free enzymes versus whole cells, and issues related to design and development of bioconversion processes. Biological and engineering problems are discussed as well as how one may arrive at both biological and engineering solutions.
This course provides a brief introduction to the field of biocatalysis in the context of process design. Fundamental topics include why and when one may choose to use biological systems for chemical conversion, considerations for using free enzymes versus whole cells, and issues related to design and development of bioconversion processes. Biological and engineering problems are discussed as well as how one may arrive at both biological and engineering solutions.
