MIT OpenCourseWare


» 進階搜尋
 課程首頁
 教學大綱
 教學時程
 相關閱讀資料
 作業
 相關資源

教學大綱


本頁翻譯進度

燈號說明

審定:邱富敏(簡介並寄信)
翻譯:李立立(簡介並寄信)
編輯:侯嘉玨(簡介並寄信)


課程描述

這個課程提供的訊息是從研究典型系統的遺傳變異獲得的,這些典型系統都是用於突變研究的,如線蟲和果蠅。也提供一些好用的新工具,可用以操作基因表達或特定腦區的某些基因。這些操作中的一部分是在離子通道層次的,而另外的部分則是在組織層次的。運用敲除、條件基因敲除或者過度表達的方法來改變發育過程中的基因表達,探討在系統中出現的這些變化。研究在人類中因為基因缺失或基因不表達而引起的疾病。

要求

課堂出席
兩個口頭報告
論文摘要
學期論文
期末考試

課程要求的細節在作業部分有描述





Class Description

This course presents the information that has been collected from studying genetic variation in model systems like nematode and drosophila for mutation studies. Also, new tools that are available to manipulate gene expression, and genes of interest in specific regions of the brain, will be presented. Some of these manipulations are at the ionic channel level, while others are at the organism level. By changing gene expression patterns during development through knockouts, conditional knockouts, or overexpression, the changes in the system can be explored. Diseases that are the result of loss of expression or missing genes in humans will also be studied.

Requirements

Attendance
Two presentations
Paper summaries
Term paper
Final exam

Details of the course requirements are described on the assignments page.




 
MIT Home
Massachusetts Institute of Technology Terms of Use Privacy