相關閱讀資料部分列出了本課程全面的參考書目。
本課程為麻省理工學院生物系提供的
本科高級研討講座之一。這些研討講座的互動性很強,是專為對利用原始研究文獻來探討學習當前生物學相關研究感興趣的學生而設的,其許多教師都是對教學有著濃厚興趣的博士後研究員。本門課程教師──Halme博士,為
HHMI(Howard Hughes醫學研究會)教育團體成員。
A full bibliography is included in the readings section of this course.
This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literature to discuss and learn about current biological research in a highly interactive setting. Many instructors of the Advanced Undergraduate Seminars are postdoctoral scientists with a strong interest in teaching. The instructor for this course, Dr. Halme, is a member of the HHMI Education Group.
每次感染都是一次侵染病原體與被侵犯宿主間的戰鬥。病原體必須逃過宿主免疫系統的重重防禦,直至能夠在宿主細胞內複製及擴散到其他細胞中,才算侵犯成功。在侵犯過程中,病原體必須逃避宿主三大免疫功能之一:檢測、啟動及效應功能。本課程將討論疾病特異性的免疫逃逸例子,及在這些例子中病原體戰勝宿主免疫系統的機制。同時探討的還有這些宿主──病原體間相互作用所揭示的免疫系統的正常功能和基本的細胞生物學過程,如蛋白質的成熟和降解。
Every infection consists of a battle between the invading pathogen and the resisting host. To be successful, a pathogen must escape the many defenses of the host immune system until it can replicate and spread to another host. A pathogen must prevent one of three stages of immune function: detection, activation, or effector function. Examples of disease-specific immune evasion and the mechanisms used by pathogens to prevail over their hosts' immune systems are discussed. Also considered is what these host-pathogen interactions reveal about the normal function of the immune system and basic cell biological processes, such as protein maturation and degradation.