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| 1 |
Introduction |
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| 2 |
Discovery of the Ubiquitin Conjugation System |
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| 3 |
Protein Degradation in Trafficking Membranes I: Endoplasmic Reticulum Associated Degradation (ERAD) Pathway |
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| 4 |
Protein Degradation in Trafficking Membranes II: Endocytosis and Lysosomal Degradation |
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| 5 |
Role of Ubiquitination in Transcriptional Regulation |
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| 6 |
Role of Ubiquitination in Cell Cycle Control and Programmed Cell Death |
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| 7 |
Ubiquitin-Like Proteins |
Assignment 1 due |
| 8 |
Functions of the Ubiquitin-Proteasome System in the Immune System |
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| 9 |
Ubiquitin and Cancer |
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| 10 |
Ubiquitin and Neurodegenerative Diseases: Alzheimer's and Parkinson's Diseases |
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| 11 |
More Diseases Involving Ubiquitin: Huntington's and Von Hippel-Lindau Disease |
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| 12 |
Too Much Degradation Can Be as Bad as Not Enough: Cystic Fibrosis and Liddle's Syndrome |
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| 13 |
Potential Therapeutic Strategies in Ubiquitin-Related Diseases |
Assignment 2 due |
| 14 |
Oral Presentations
Final Comments and Course Evaluation |
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