20.441 / 2.79J / 3.96J / HST.522J 2003秋季課程：生物材質與組織間的反應(BE.441)(Biomaterials-Tissue Interactions (BE.441), Fall 2003)
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髖關節義肢是一個已受廣泛使用之永久型醫療植體的成功案例(圖片由OCW提供)
The hip prosthesis is a widely used and successful example of a permanent medical implant. (Image courtesy of OCW.)
The hip prosthesis is a widely used and successful example of a permanent medical implant. (Image courtesy of OCW.)
課程重點
此課程包含廣泛的授課筆記並含完整的作業習題
This course features extensive lecture notes as well as a complete set of homework assignments.
This course features extensive lecture notes as well as a complete set of homework assignments.
課程描述
這門課程是介紹以應用於組織工程學中設計醫療植體、人工器官和基質為主的材料科學和細胞生物學。內容包括生醫材料表面特性檢測和蛋白質吸附於生醫材料表面的分析。分子和細胞與生醫材料的交互作用並以單元細胞過程來進行分析，譬如基質合成、降解和收縮。同時包括創傷癒合和植入不同器官後組織重塑之作用機制。其它領域則包括組織和器官再生；植體和義肢根據生醫材料與組織交互作用的設計；及藉由參考例案以比較分析完整原型，生物可分解型和生物可置換型等各種植體。並會探討組織和器官之生理功能恢復的評斷標準。
This course is an introduction to principles of materials science and cell biology underlying the design of medical implants, artificial organs, and matrices for tissue engineering. Topics include methods for biomaterials surface characterization and analysis of protein adsorption on biomaterials. Molecular and cellular interactions with biomaterials are analyzed in terms of unit cell processes, such as matrix synthesis, degradation, and contraction. It also covers mechanisms underlying wound healing and tissue remodeling following implantation in various organs. Other areas include tissue and organ regeneration; design of implants and prostheses based on control of biomaterials-tissue interactions; comparative analysis of intact, biodegradable, and bioreplaceable implants by reference to case studies. Also addressed are criteria for restoration of physiological function for tissues and organs.
This course is an introduction to principles of materials science and cell biology underlying the design of medical implants, artificial organs, and matrices for tissue engineering. Topics include methods for biomaterials surface characterization and analysis of protein adsorption on biomaterials. Molecular and cellular interactions with biomaterials are analyzed in terms of unit cell processes, such as matrix synthesis, degradation, and contraction. It also covers mechanisms underlying wound healing and tissue remodeling following implantation in various organs. Other areas include tissue and organ regeneration; design of implants and prostheses based on control of biomaterials-tissue interactions; comparative analysis of intact, biodegradable, and bioreplaceable implants by reference to case studies. Also addressed are criteria for restoration of physiological function for tissues and organs.
