第一部分:系统微生物学-将细胞视成一个完全搅拌反应器 Part I: Systems Microbiology - 'The Cell as a Well-stirred Bioreactor' |
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简介 Introduction
酵素动力学
Michaelis-Menten Kinetics |
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| 2 |
平衡结合 Equilibrium Binding
合作现象
Cooperativity |
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| 3 |
嗜菌体 Lambda Phage
多稳定性
Multistability |
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| 4 |
多稳定性(继续上次课程) Multistability (cont.) |
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| 5 |
合成基因开关 Synthetic Genetic Switches |
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| 6 |
稳定性分析 Stability Analysis |
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| 7 |
大肠杆菌的趋化性介绍 Introduction E. coli Chemotaxis |
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| 8 |
格式化和稳健形趋化性模型的比较 Fine-tuned versus Robust Chemotaxis Models |
缴交第一次的习题集 Problem set 1 due |
| 9 |
掩饰趋化性 Wrapping up Chemotaxis |
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| 10 |
基因震荡器 Genetic Oscillators |
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| 11 |
基因震荡器(继续上次课程) Genetic Oscillators (cont.) |
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| 12 |
随机化学动力 Stochastic Chemical Kinetics |
缴交第二次的习题集 Problem set 2 due |
| 13 |
随机化学动力学(继续上次课程) Stochastic Chemical Kinetics (cont.) |
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第二部分:细胞系统生物学-将细胞视成一个既有浓度梯度的分隔系统 Part II: Cell Systems Biology - 'The Importance of Diffusion and Gradients for Cellular Regulation' |
| 14 |
细胞系统生物学简介 Introduction Cell Systems Biology
Fick法则
Fick's Laws |
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| 15 |
局部刺激 Local Excitation
整体抑制理论
Global Inhibition Theory |
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| 16 |
局部刺激(继续上次课程) Local Excitation (cont.)
整体抑制理论(继续上次课程)
Global Inhibition Theory (cont.) |
缴交第三次的习题集 Problem set 3 due |
| 17 |
大肠杆菌中快速极间震荡 Rapid Pole-to-pole Oscillations in E. coli |
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| 18 |
大肠杆菌中快速极间震荡(继续上次课程) Rapid Pole-to-pole Oscillations in E. coli (cont.) |
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| 19 |
真核生物的梯度感应模型 Models for Eukaryotic Gradient Sensing |
缴交第四次的习题集 Problem set 4 due |
| 20 |
真核生物的梯度感应模型(继续上次课程) Models for Eukaryotic Gradient Sensing (cont.) |
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| 21 |
细胞骨架动力学建模 Modeling Cytoskeleton Dynamics |
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| 22 |
细胞骨架动力学建模(继续上次课程) Modeling Cytoskeleton Dynamics (cont.) |
缴交第五次的习题集 Problem set 5 due |
第三部分:发育系统生物学-由单一细胞建构一个生物体 Part III: Developmental Systems Biology - 'Building an Organism Starting From a Single Cell' |
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数量感应 Quorum Sensing |
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| 24 |
期末习题集咨询时间 Final Problem Set Question Hour |
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| 25 |
果蝇发育学 Drosophila Development |
期末习题集缴交时间 Take home final due |