5.08J / 7.08J 2004春季课程：生物化学II(Biological Chemistry II, Spring 2004)
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β－酮酰基酰基载体蛋白合成酶I与硫乳菌素形成的复杂物结构，此为药物设计的示意图。PDB ID: 1FJ4. Price, A. C., Choi, K., Heath, R. J., Li, Z., White, S. W., Rock, C. O.〈硫乳霉素与浅蓝菌素对β－酮酰基酰基载体蛋白合成酶的抑制作用：结构与机制〉，《生物化学杂志》，276 pp. 6551 (2001).（由结构生物学合作研究协会提供图片，H.M.Berman, J.Westbrook, Z.Feng, G.Gilliland, T.N.Bhat, H.Weissig, I.N.Shindyalov, P.E.Bourne，蛋白质数据库，《核酸研究》，28 pp. 235-242 (2000).)
The Structure Of Beta-Ketoacyl-[Acyl Carrier Protein] Synthase I In Complex With Thiolactomycin, Implications For Drug Design. PDB ID: 1FJ4. Price, A. C., Choi, K., Heath, R. J., Li, Z., White, S. W., Rock, C. O.: Inhibition of Beta-Ketoacyl-[Acyl Carrier Protein] Synthases by Thiolactomycin and Cerulenin: Structure and Mechanism J.Biol.Chem. 276 pp. 6551 (2001). (Image courtesy of the Research Collaboratory for Structural Bioinformatics. H.M.Berman, J.Westbrook, Z.Feng, G.Gilliland, T.N.Bhat, H.Weissig, I.N.Shindyalov, P.E.Bourne The Protein Data Bank. Nucleic Acids Research, 28 pp. 235-242 (2000).)
The Structure Of Beta-Ketoacyl-[Acyl Carrier Protein] Synthase I In Complex With Thiolactomycin, Implications For Drug Design. PDB ID: 1FJ4. Price, A. C., Choi, K., Heath, R. J., Li, Z., White, S. W., Rock, C. O.: Inhibition of Beta-Ketoacyl-[Acyl Carrier Protein] Synthases by Thiolactomycin and Cerulenin: Structure and Mechanism J.Biol.Chem. 276 pp. 6551 (2001). (Image courtesy of the Research Collaboratory for Structural Bioinformatics. H.M.Berman, J.Westbrook, Z.Feng, G.Gilliland, T.N.Bhat, H.Weissig, I.N.Shindyalov, P.E.Bourne The Protein Data Bank. Nucleic Acids Research, 28 pp. 235-242 (2000).)
课程重点
工具部分包含了各种分子影像程序的信息，而这些程序是被用来观察本课程内的三维结构。
The tools section includes information about various molecular graphics programs used to view three-dimensional structures in this course.
The tools section includes information about various molecular graphics programs used to view three-dimensional structures in this course.
» View this course in Simplified Chinese courtesy of China Open Resources for Education (CORE).
课程描述
本课程探讨生物中一个更高级机制的处理，重点将放在用来阐明这些步骤如何与细胞环境相适应，解释生化调控的实验方法上。课程专题包括：能量和力转换的生物分子机器，生物合成与降解途径的调控，以及核酸的结构与功能。
This course deals with a more advanced treatment of the biochemical mechanisms that underlie biological processes. Emphasis will be given to the experimental methods used to unravel how these processes fit into the cellular context as well as the coordinated regulation of these processes. Topics include macromolecular machines for energy and force transduction, regulation of biosynthetic and degradative pathways, and the structure and function of nucleic acids.
This course deals with a more advanced treatment of the biochemical mechanisms that underlie biological processes. Emphasis will be given to the experimental methods used to unravel how these processes fit into the cellular context as well as the coordinated regulation of these processes. Topics include macromolecular machines for energy and force transduction, regulation of biosynthetic and degradative pathways, and the structure and function of nucleic acids.
技术需求
Technical Requirements
需要用到RasMol软件，以打开本站点上的 .spt 和 .pdb格式的文件。
RasMol software is required to run the .spt and .pdb files found on this course site.
