10.492-2 2004秋季课程：整合化学工程专题I：生物触媒导论(Integrated Chemical Engineering Topics I: Introduction to Biocatalysis, Fall 2004)
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枯草杆菌脂?的结晶构造：最小的a/b水解酵素。PDB ID: 1I6W。 van Pouderoyen, G., T. Eggert, K. E. Jaeger, B. W. Dijkstra：枯草杆菌脂?的结晶构造：最小的alpha/beta摺叠水解酵素。《分子生物学期刊》 309, issue 1 (May 25, 2001): 215-26.（图片提供：结构生物资讯研究共同实验室，H.M.Berman, J.Westbrook, Z.Feng, G.Gilliland, T.N.Bhat, H.Weissig, I.N.Shindyalov, P.E.Bourne 蛋白质数据库，《核酸研究》, 28 pp. 235-242 (2000).）
The Crystal Structure Of Bacillus Subtilis Lipase: A Minimal a/b Hydrolase Enzyme. PDB ID: 1I6W. van Pouderoyen, G., T. Eggert, K. E. Jaeger, B. W. Dijkstra: The crystal structure of Bacillus subtilis lipase: a minimal alpha/beta hydrolase fold enzyme. J. Mol. Biol. 309, issue 1 (May 25, 2001): 215-26. (Image courtesy of the Research Collaboratory for Structural Bioinformatics. Berman, H. M., J. Westbrook, Z. Feng, G. Gilliland, T. N. Bhat, H. Weissig, I. N. Shindyalov, and P. E. Bourne. "The Protein Data Bank." Nucleic Acids Research 28 (2000): 235-242.)
The Crystal Structure Of Bacillus Subtilis Lipase: A Minimal a/b Hydrolase Enzyme. PDB ID: 1I6W. van Pouderoyen, G., T. Eggert, K. E. Jaeger, B. W. Dijkstra: The crystal structure of Bacillus subtilis lipase: a minimal alpha/beta hydrolase fold enzyme. J. Mol. Biol. 309, issue 1 (May 25, 2001): 215-26. (Image courtesy of the Research Collaboratory for Structural Bioinformatics. Berman, H. M., J. Westbrook, Z. Feng, G. Gilliland, T. N. Bhat, H. Weissig, I. N. Shindyalov, and P. E. Bourne. "The Protein Data Bank." Nucleic Acids Research 28 (2000): 235-242.)
课程重点
课程描述
本课程将以程序设计观点提供生物触媒领域的简介。基本的主题包括:为何及何时可能选择使用生物系统来进行化学转化、考量使用分离酵素或完整细胞，以及与设计和开发生物转化程序相关的议题。课程中并将讨论生物和工程的问题，以及如何才可能同时达成生物和工程的解决方案。
This course provides a brief introduction to the field of biocatalysis in the context of process design. Fundamental topics include why and when one may choose to use biological systems for chemical conversion, considerations for using free enzymes versus whole cells, and issues related to design and development of bioconversion processes. Biological and engineering problems are discussed as well as how one may arrive at both biological and engineering solutions.
This course provides a brief introduction to the field of biocatalysis in the context of process design. Fundamental topics include why and when one may choose to use biological systems for chemical conversion, considerations for using free enzymes versus whole cells, and issues related to design and development of bioconversion processes. Biological and engineering problems are discussed as well as how one may arrive at both biological and engineering solutions.
