7.90J / 6.874J 2005春季课程：计算性实用基因体(Computational Functional Genomics, Spring 2005)
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蛋白质编码基因转录的三个阶段。（图片由David Gifford教授提供。）
Three steps in the transcription of protein-coding genes. (Image by Prof. David Gifford.)
课程重点
课程描述
The course focuses on casting contemporary problems in systems biology and functional genomics in computational terms and providing appropriate tools and methods to solve them. Topics include genome structure and function, transcriptional regulation, and stem cell biology in particular; measurement technologies such as microarrays (expression, protein-DNA interactions, chromatin structure); statistical data analysis, predictive and causal inference, and experiment design. The emphasis is on coupling problem structures (biological questions) with appropriate computational approaches.
技术要求
Technical Requirements
任何数量的生物学序列类比软件工具都可用于引入在本课程站点上的FASTA 格式序列（.fa）文档。要求使用MATLAB® software，查看并运行在本课程站点上的.m和mat文档。可使用附录浏览软件，比如Ghostscript/Ghostview，查看本课程站点上的ps 文档。文档解压缩软件，比如Winzip®或者StuffIt®，可用于打开本课程站点上的zip 文档。
Any number of biological sequence comparison software tools can be used to import the FASTA formatted sequence (.fa) files found on this course site. MATLAB® software is required to view and run the .m and .mat files found on this course site. Postscript viewer software, such as Ghostscript/Ghostview, can be used to view the .ps files found on this course site. File decompression software, such as Winzip® or StuffIt®, is required to open the .zip files found on this course site.
