教学大纲
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课程大纲
在分子尺度上分析并设计在生物科技和生物医学工程中与生物系统有直接接触的材料。要讲授的题目包括：生物和合成分子以及表面之间的相互作用；对用于控制细胞功能的材料的设计、合成及处理；最先进的材料科学知识在生物组织工程、药物传送、生物感应器和对细胞有导引作用的表面（的设计中）的应用。
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分子水平上对生物材料的设计与合成 I：可生物降解的高分子固体
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高分子固体制成的药物可控释放装置
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可降解的高分子材料与生物组织工程
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分子水平上对生物材料的设计与合成 II: 水溶胶
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分子水平上对生物材料的设计与合成 III: 生物陶瓷与生物复合材料
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生物分子与合成分子的组合
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能对外界刺激作出反应的生物材料
课程信息
目标
讲解在分子尺度上设计生物材料的过程中所涉及的基本概念（物理化学、化学以及材料物理学）
讲解在分子尺度上设计生物材料的过程中所涉及的基本概念（物理化学、化学以及材料物理学）
那些不在本课程范围内的概念只有在与所要讲解的题目有直接联系时才会加以讨论。Concepts not within the scope of this course will only be discussed where direct connections are made with the proposed outline:
（本系）别的课程所覆盖的概念：
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生物材料表面（3.051“材料的生物医学应用”和研究生课程 BE.441J/2.79J/3.96J“生物材料和生物组织的相互作用”）
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有生物机械性能的人造器官（2.782J/3.961J“生物医学设备和移植体的设计”）
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生物材料存在下的伤口愈合（BE.441J/2.79J/3.96J “生物材料和生物组织的相互作用”）
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自然生物材料的结构与基于肽键的自我组装（“生物材料的分子结构”）
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生物材料系统中的传递（“细胞与组织工程”）
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配合基与接受体的相互作用以及模拟（ “细胞与组织工程”，“代谢与细胞工程”，和 BE.420/10.538J“生物分子与细胞动力学”）
大体上在“分子原理”范围之外的概念
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生物材料的力学（力学已经是材料工程系和生物工程系核心课程里很显著的一部分了）；大体上充当被动角色的材料（例如用于免疫隔离的膜）－我们只会讲解（生物材料的）微观结构有（主动的）发出（生物）信号功能的例子，例如，骨骼。
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普通主体（即非表面的）材料的性质，例如，具有形状记忆功能的生物材料
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材料的定性描述方法（在3.051里已经讨论得很充分了）
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为了更详细地讲解“分子水平”的内容，对于材料的处理不会讨论很深，但在一些具体例子的分析中会有所涉及。（这个领域中）一些我们会略过的内容有：三维结构的合成（3DP，MAPLE，激光微细加工，以及三维高分子聚合）。
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一般的批量生产中会涉及的问题，比如无菌化和与政府规章管理有关的内容（只是因为我们的课程时间不够）。
课程评分
30%: 课后作业，其可能包括：
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习题
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对最近出版的研究文献的阅读和评价
45%: 3次一小时长的考试
25%: 一个大的学期课题
学术诚实
很简单，就是要诚实（知之为知之，不知为不知）。我们（老师）是真心想教授一些知识，你们呢也是想真正有所收获。（所以，没有必要弄虚作假。）
Course Outline
Analysis and design at a molecular scale of materials used in contact with biological systems, including biotechnology and biomedical engineering. Topics include molecular interactions between bio- and synthetic molecules and surfaces; design, synthesis, and processing approaches for materials that control cell functions; and application of state-of-the-art materials science to problems in tissue engineering, drug delivery, biosensors, and cell-guiding surfaces.
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Molecular Design and Synthesis of Biomaterials I: Biodegradable Polymeric Solids
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Controlled Release Devices from Solid Polymers
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Degradable polymers and Tissue Engineering
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Molecular Design and Synthesis of Biomaterials II: Hydrogels
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Molecular Design and Synthesis of Biomaterials III: Bioceramics and Biocomposites
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Combining Biological and Synthetic Molecules
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Stimuli-Responsive Biomaterials
Course Information
Mission Statement of this Course
To teach the fundamental concepts (physical chemistry, chemistry, and materials physics) behind the design of materials with biological functions at a molecular scale.
To teach the fundamental concepts (physical chemistry, chemistry, and materials physics) behind the design of materials with biological functions at a molecular scale.
Concepts not within the scope of this course will only be discussed where direct connections are made with the proposed outline:
Concepts Covered by Other Courses
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Biomaterials surfaces (covered by 3.051 "Biomedical Applications of Materials" and at the graduate level in 20.441J/2.79J/3.96J "Biomaterials-Tissue Interactions").
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Biomechanical artificial organs (covered by 2.782J/3.961J "Design of Medical Devices and Implants").
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Wound healing in the presence of biomaterials (covered by 20.441J/2.79J/3.96J "Biomaterials-Tissue Interactions").
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Structure of native biological materials and peptide-based self-assembly (covered by "Molecular Structure of Biological Materials").
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Transport in biomaterials systems (covered by "Cell and Tissue Engineering").
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Receptor-ligand interactions and modeling (covered by "Cell and Tissue Engineering," "Metabolic and Cell Engineering," and 20.420/10.538J Biomolecular Kinetics and Cellular Dynamics).
Concepts Largely Outside the Purview of "Molecular Principles"
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Mechanics of biomaterials (mechanics already a significant part of both DMSE and BE core classes); materials which play a largely passive role (e.g. immunoisolation membranes)- we will cover cases where microstructure has signaling functions, e.g. bone.
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General bulk materials properties, e.g. shape memory biomaterials.
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Materials characterization approaches (well discussed in 3.051).
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Processing will not be covered in depth in order to cover 'molecular' areas more thoroughly. It will be included in case studies and specific examples. Interesting areas that we will forego: 3D structure synthesis (3DP, MAPLE, laser microfabrication and 3D polymerization).
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General mass production issues such as sterilization, and regulatory issues (just not enough time).
Evaluation
30%: Homework, which may include:
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Problem sets
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Critical evaluation of recent research literature
45%: Three 1 hour Exams
25%: Term Project
Academic Honesty
Be honest, it's that simple. We want to teach, you want to learn.
