这门课程是介绍以应用于组织工程学中设计医疗植体、人工器官和基质为主的材料科学和细胞生物学。内容包括生医材料表面特性检测和蛋白质吸附于生医材料表面的分析。分子和细胞与生医材料的交互作用并以单元细胞过程来进行分析，譬如基质合成、降解和收缩。同时包括创伤愈合和植入不同器官后组织重塑之作用机制。其它领域则包括组织和器官再生；植体和义肢根据生医材料与组织交互作用的设计；及藉由参考例案以比较分析完整原型，生物可分解型和生物可置换型等各种植体。并会探讨组织和器官之生理功能恢复的评断标准。

书本

Yannas, I. V. 《成人组织和器官的再生》. New York: Springer, 2001. ISBN: 0387952144.

先修课号

3.091或5.11或5.111或5.112

2.005或5.60

7.012或 7.013

This course is an introduction to principles of materials science and cell biology underlying the design of medical implants, artificial organs, and matrices for tissue engineering. Topics include methods for biomaterials surface characterization and analysis of protein adsorption on biomaterials. Molecular and cellular interactions with biomaterials are analyzed in terms of unit cell processes, such as matrix synthesis, degradation, and contraction. It also covers mechanisms underlying wound healing and tissue remodeling following implantation in various organs. Other areas include tissue and organ regeneration; design of implants and prostheses based on control of biomaterials-tissue interactions; comparative analysis of intact, biodegradable, and bioreplaceable implants by reference to case studies. Also addressed are criteria for restoration of physiological function for tissues and organs.

Text

Yannas, I. V. Tissue and Organ Regeneration in Adults. New York: Springer, 2001. ISBN: 0387952144.

Prerequisites

3.091 or 5.11 or 5.111 or 5.112

2.005 or 5.60

7.012 or 7.013