20.011J / 2.772J 2004春季课程：生物分子系统之统计热力学(BE.011J)(Statistical Thermodynamics of Biomolecular Systems (BE.011J), Spring 2004)
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基因是一种含编译蛋白质制造命令的特殊碱基序列。蛋白质执行大部分生命功能，甚至组成细胞的主要结构。蛋白质是由称为胺基酸的较小次单元所组成的大型复杂分子。(感谢美国能源部 人类基因体计划提供图片。)
Genes are specific sequences of bases that encode instructions on how to make proteins. It’s the proteins that perform most life functions and even make up the majority of cellular structures. Proteins are large, complex molecules made up of smaller subunits called amino acids. (Illustration courtesy of the Human Genome Program of the U.S. Department of Energy.)
课程重点
本课程之特色为包括一组完整的 问题集与考试题目，内容还包括一些计算机模拟工具。
This course features a complete set of problem sets and exams along with some computer simulation tools.
课程描述
本课程提供了生物系统的物理化学入门。主题包括：以统计力学、化学位能、平衡态、协同键溶性、溶液中/界面间的巨分子行为及溶解等现象来连接巨观热力学性质与微观分子性质。范例问题包含蛋白质结构、基因体分析、单分子生物力学及生医材料等。
This course provides an introduction to the physical chemistry of biological systems. Topics include: connection of macroscopic thermodynamic properties to microscopic molecular properties using statistical mechanics, chemical potentials, equilibrium states, binding cooperativity, behavior of macromolecules in solution and at interfaces, and solvation. Example problems include protein structure, genomic analysis, single molecule biomechanics, and biomaterials.
技术需求
需要MATLAB® 软件执行本课程网站上提供的.m及.fig文件MATLAB® software is required to run the .m and .fig files found on this course site.
